FORMULATION & EVALUATION OF TOLNAFTATE LOADED INVASOMAL GEL
Chhotelal Patel, Mr. Deepak Tripathi, Mr. Manvendra Singh Kaurav Dr. Avinash
Krishnrao Kondalkar, Mr. Muraree Lal
ABSTRACT
The growing number of immunosuppressed individuals who are at increased risk for developing fungi illnesses, fungi diseases need more attention than ever before. Transdermal drug delivery is the term for the method of administering medication through the skin to achieve a local or systemic treatment that has been given clinical approval. Invasomes are a new type of vesicle penetration-enhancing capabilities, boosting or improving medication absorption via the skin. Thus, this study aims at formulation & evaluation of Tolnaftate loaded Invasomal gel. The formulation & evaluation of gel was done by standard parameters. Results showed that the highest % entrapment efficiency was recorded for F4 formulation which is 72.32±0.18. Also, the average vesicle size for F4 was noticed to be 215.65±0.22nm. The zeta potential for F4 was seen to be -38.45mV. Further three formulation of ivasomal gel was made & evaluated for various parameters. The maximum % of drug content was observed for IG2 gel formulation as 99.45±0.23. The Extrudability (g) & Spreadibility (g.cm/sec) was observed to be 145±4 & 10.26±0.32 while Viscosity (cps) & pH was observed to be 3365±11 & 6.78±0.25. The In vitro drug release study pattern for IG 2 indicate that the drug release at 12 hour was 99.15±0.21. The highest R2 value was found to be 0.986, so the reaction found to follow the higuchi kinetics.The result of stability studies indicates that the formulated invasomal gel is stable for maximum 2 months as after that the drug content was observed to be reduced. From results it can be concluded that the formed invasomal gel of Tolnaftate may be useful to treat fungal skin infections.
[Full Text Article]