FORMULATION, DEVELOPMENT AND EVALUATION OF OCULAR IN SITU GEL OF MOXIFLOXACIN AND KETOROLAC TROMETHAMINE
Anjani Shukla*, Shradha Shende, Dr. Navjot Singh
ABSTRACT
In situ gelling system of moxifloxacin and ketorolac tromethamine was successfully formulated using polymeric combination of gelling agents Pluronic F127, Carbopol 934 as, temperature sensitive and pHsensitive respectively along with HPMC 15cps as viscosity enhancing agent. Formulation F6 to F9 show poor gelling capacity in simulated physiological conditions of pH and temperature because of comparatively less concentration of Pluronic F127 in F6 and F9 and due to low concentration of Carbopol in F1, F3, F4 and F5 formulation show better gelling capacity. The comparative study of viscosity was done at 10 rpm. F3, F4, and F5 show comparatively better viscosity and good consistency gel. The In vitro drug release data of the optimized formulation was subjected to goodness of fit test by linear regression analysis according to zero order and first order kinetic equation in order to determine the mechanism of drug release. When the regression coefficient values of were compared, it was observed that ‘r’ values of Higuchi was maximum hence indicating drug release from formulations was found to follow Higuchi release kinetics. In conclusion, evaluation of in-situ gel is determined to ensure that the prepared preparation meets the standard and is safe. In the chemical evaluation in-situ gel determined the diffusion of the active substance of a compound by measuring its concentration.
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