ENHANCEMENT OF SOLUBILITY AND FORMULATION DEVELOPMENT OF SPARFLOXACIN FAST DISSOLVING WAFERS
Om Prakash Mishra*, Brajesh Kumar Arjariya, Ankit Mehra
ABSTRACT
Poorly soluble medication solubilization is a frequent problem in formulation design and development as well as screening studies of novel chemical entities. Fast-dissolving wafers are a new oral dosage form that is being used by patients all over the world. Even in an acute condition, these dose forms might be employed to provide immediate relief. This study deals with enhancement of solubility and formulation development of Sparfloxacin fast dissolving wafers. Oral wafers of Sparfloxacin was prepared by solvent casting method & evaluated for various parameters. Results showed that in solid dispersion it was found that in Drug: PVP K-90 (1:1) % Solubility Enhancement was found 309.412%. For F3 formulation the folding endurance was found to be 185±3 the disintegration time was found to be 1.2±0.1 min, tensile strength was found to be 0.745±0.032 kg/cm2, from the results it can be concluded that prepared oral Moisture content observed to be 1.85±0.14%, the assay percent obtained as 99.05±0.15. The % assay in stability study of wafer was found to be 98.12±0.32 hence stable for 3 months. Thus, it can be concluded that oral wafers of Sparfloxacin to treat bacterial respiratory infections and sinusitis.
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