FORMULATION, DEVELOPMENT AND EVALUATION OF ADAPALENE LOADED TRANSFERSOMES GEL FOR EFFECTIVE ACNE TREATMENT
Anirudh Singh Parihar*, Kuldeep Chaurasiya, Dr. Kapil Purohit
ABSTRACT
Acne vulgaris at some point during adolescence affects 9.4% of people worldwide. it can range in severity from a few spots on the face, neck, back, and chest to a more serious condition that may leave scars and affect one's self-esteem. Transferosomes, a vesicular drug-carrier system, have recently been demonstrated to improve transdermal drug delivery when applied topically without occlusive contact. As the gels are biocompatible, the transfersome formulation embded in gel will be more effective in acne treatment. Thus, this study deals with Formulation, development and evaluation of Adapalene loaded transfersomes gel for effective acne treatment. Transferosomes were prepared by standard protocol with considering optimization of various parameters. Further transferosomal gel is evaluated for various parameters. Results showed that average vesicle size of optimized formulation F-12 was 165.58 nm while Zeta potential was found to be -35.65. % Entrapment efficiency of optimized transferosomal formulation (F-12) was found 72.12%. The viscosity of prepared gel was 3450±15cps, % assay was 99.15±0.36, Extrudability was 168±4g and Spreadibility (g.cm/sec) was found that 12.23±0.15 (g.cm/sec) respectively. In vitro drug release from Transfersomes was carried out using Franz diffusion cell method and found 98.85% in 12 hr. In first 30 min it was 19.98 drug release which slightly high. Stability study data was revealed that the optimized formulation (F-12) stable after 3 month of storage at 4ºC while at 25-28±2°C, the formulation was found unstable.
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