FORMULATION, DEVELOPMENT AND EVALUATION OF ANTIFUNGAL DRUG LOADED TRANSFERSOMES FOR EFFECTIVE TOPICAL FUNGAL TREATMENT
Amit Singh Baghel*, Mr. Praveen Kumar, Dr. Pratyush Jain, Dr. Om Prakash Agrawal
ABSTRACT
The objective of this study is to formulate and evaluate econazole loaded transfersomes for enhanced drug delivery. Econazole is an antifungal drug used to treat various fungal infections. However, its efficacy is limited by poor skin permeation and low bioavailability. Transfersomes are flexible lipid vesicles that can enhance drug delivery through the skin by penetrating the stratum corneum. The optimized transfersomes were characterized for entrapment efficiency and particle size. The in vitro drug release study was conducted using a Franz diffusion cell, and the results showed sustained drug release over 12 hours. The permeation study was carried out using and the transfersomes showed significantly higher permeation compared to the free drug solution. In conclusion, the formulated transfersomes showed promising results in enhancing the skin permeation and bioavailability of econazole. The results suggest that transfersomes could be a potential carrier for econazole in the treatment of fungal infections.
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