FORMULATION AND CHARACTERIZATION OF ETHOSOMAL GEL OF OZENOXACIN FOR TREATMENT OF TOPICAL SKIN INFECTION
Akash Jha*, Dr. Avinash Krishnarao Kondalkar, Mr. Muraree Lal
ABSTRACT
The skin infections remain the fourth most common cause of nonfatal disease burden globally. In contrast to oral drug delivery systems, transdermal drug delivery systems (TDDS) have shown promising results because they avoid gastrointestinal interferences and first-pass drug metabolism. Ethosomes are noninvasive drug delivery systems that allow medications to penetrate deeply into the epidermis layers and/or the bloodstream. Thus, this study deals with formulation and characterization of ethosomal gel of ozenoxacin for treatment of topical skin infection. The Vesicle size of formulation EF1 to EF8 was found to be 110.25 to 185.45nm. The Minimum Vesicle size was found in formulation EF7 (110.25 nm). Zeta potential of optimized formulation EF7 was found to be high (-7.97±0.67). The maximum entrapment efficiency of ethosomal vesicles as determined by ultracentrifugation was 73.02% for ethosomal formulation containing 20% ethanol (EF3). The percentage drug content of ethosomal gel was found to be 97.74±1.066 to 99.24±0.564 formulation G-1 to G-3 respectively. The ‘r2’ values of Higuchi was maximum i.e. 0.979 hence indicating drug release from formulations was found to follow Higuchi kinetics. Thus, from the results obtained it can be concluded that ethosomal gel of ozenoxacin can eefectively be used for treating skin infections.
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