DEVELOPMENT AND EVALUATION OF TENOXICAM LOADED EMULGEL FOR ENHANCED TRANSDERMAL DELIVERY
Piyush Rathore*, Sandesh Asati, S. K. Lariya
ABSTRACT
The present study is to increase the transport of tenoxicam through transdermal route, and also to present it as a possible replacement for the oral NSAID therapy. The present investigation was to develop a tenoxicam emulgel with reduced particle size in order to improve the bioavailability of the anti-inflammatory drug, Tenoxicam. Emulgel is helpful in enhancing spreadability, viscosity and extrusion, this novel drug delivery become popular. Moreover, they will become a solution for loading hydrophobic drugs in water soluble gel bases for the long term stability. Similarly in the study, topical emulgels of Tenoxicam were formulated and subjected to physicochemical studies i.e. rheological studies, spreading coefficient studies and in vitro release studies. In vitro release of the tests formulations were performed to determine drug release from emulgel rate and duration of drug release. From the in vitro studies, formulation F3 showed maximum release of 99.41% in 6 hrs.
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