FORMULATION DEVELOPMENT AND EVALUATION OF BALSALAZIDE LOADED NANOSPONGES FOR IBD
Brijesh Kumar, Rajeev Malviya, S. K. Lariya
ABSTRACT
Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD). Site-targeted drug release allows obtaining a high drug concentration in injured tissues and less systemic adverse effects, as consequence of less/null drug absorption in small intestine. This review focused on the reported contributions in the last four years to improve the effectiveness of treatments of inflammatory bowel diseases. The aim of the present research work was to develop sustained release nanosponges formulation of Balsalazide targeted to colon by using various pH dependent polymers. The maximum encapsulation efficiency was also found maximum in formulation F3 (89.78±0.45), select as optimized formulation for further evaluation. The surface charge of optimized formulation of nanosponges F-3 was found -20.2 and average particle size was found 52.74±1.05. The analytical characterization showed good purity of the drug. In vitro drug release showed a good release profile of prepared optimized-sponges formulation.
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