IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

FORMULATION AND EVALUATION OF ACECLOFENAC IN-SITU GEL FOR THE TREATMENT OCULAR INFLAMMATORY DISEASES

Abhinav P. Mehta*, Ujwala P. Chaudhari, Kalpesh S. Patil, Sagar S. Kothari

ABSTRACT

In situ gels are solutions or suspensions that can undergo rapid sol-to-gel transformation when stimulated by external stimuli such as temperature and pH during instillation. The primary disadvantage of eye drops is that the drug is rapidly eliminated from the precorneal region, resulting in poor bioavailability and therapeutic efficacy. To overcome these constraints, an ion-triggered in situ gel for sustained aceclofenac delivery was developed. Aceclofenac is a medication used to treat eye inflammation. The in situ gel was made up of two polymers: hydroxypropyl methylcellulose (HPMC) and sodium alginate. Formulations were chosen and further characterised for viscosity, in vitro release studies based on various physicochemical evaluation parameters such as pH, clarity, and gelling capacity. The optimised in situ gel (A5) achieved 90.14 percent drug release in 12 hours, demonstrating the in situ gel's sustained release nature. Thus, when compared to conventional systems, in situ gel-based systems containing gums can be a valuable approach for ophthalmic drug delivery.

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