FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF LAMIVUDINE
Shivangi Thakur*, Ms. Shradha Shende, Dr. Navjot Singh
ABSTRACT
An ideal drug delivery system should aid in the optimization of drug therapy by delivering an appropriate amount to the intended site and at a desired rate. Hence, the DDS should deliver the drug at a rate dictated by the needs of the body over the period of treatment. An oral drug delivery system providing a uniform drug delivery can only partly satisfy therapeutic and biopharmaceutical needs, as it doesn’t take in to account the site specific absorption rates within the gastrointestinal tract (GIT). Therefore, there is a need of developing drug delivery system that release the drug at the right time, at the specific site and with the desired rate. Matrix system was the earliest oral extended release platform for medicinal use. The current study focuses on the use of tamarind seed polysaccharide (TSP) as an excipient in medication delivery systems. The planned work's major goal is to concentrate on the industrial applications of this polysaccharide, with a special focus on its physical and chemical characteristics for the development of novel drug delivery methods. This goal drives the development of novel synthetic excipients that take advantage of the current limitations in terms of toxicity, compatibility, and cost effectiveness. In this work, we attempted to take use of TSP's advantages for Lamivudine oral delivery. An attempt was made to construct and describe Lamivudine sustained release matrix tablets for HIV therapy utilizing a mix of TSP and ethylcellulose. These results show that all matrix tablet formulations release the drug in a sustained manner for up to 24 hours, but formulation F2 released 98.82 percent of the drug and the release was found to be extended for up to 24 hours, indicating that the formulation could be used as a once daily sustained release matrix tablet of Lamivudine. The formulation's characteristics and test requirements were both satisfactory.
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