FORMULATION, DEVELOPMENT AND EVALUATION OF TRANSFERSOMES GEL OF TERBINAFINE HYDROCHLORIDE FOR EFFECTIVE TREATMENT OF TOPICAL FUNGAL DISEASE
Minakshi Vasantrao Khubalkar, Dr. Vishnu Raj, Dr. S. K. Lariya
ABSTRACT
Occurrence of skin fungal infections is increasing nowadays and their presence is more prominent in patients suffering from immune compromised diseases like AIDS. Skin fungal infections are a major cause of visits by patients to dermatology clinics. Treatment approaches include both topical and oral antifungal agents. The topical route is generally preferred due to the possible side effects of oral medication. Advances in the field of formulation may soon render outdated conventional products such as creams, ointments and gels. Several carrier systems loaded with antifungal drugs have demonstrated promising results in the treatment of skin fungal infections. The aim of the present study was to investigate the potential of transfersomal gel formulations for transdermal delivery of terbinafine hydrochloride and to evaluate the effect of lipid concentration, ethanol concentration, drug concentration and stirrer time. Characterization of transfersomes performed by vesicle size, surface charge, entrapment efficiency and stability study. Characterization of transfersomes containing gel performed by the measurement of viscosity, pH measurements, drug content, extrudability study, spreadability and in vitro drug diffusion study. It was found that viscosity of prepared gel was 3652±15cps, % assay was 98.85±0.23, extrudability was 145±6gm and spreadability was found that 12.25±0.35 (g.cm/sec) respectively. The prepared gel containing terbinafine hydrochloride-loaded transfersomal formulation was optimized and can be use for topical preparation for its antifungal affect. The results were obtained which showed that transfersomal gel was a promising candidate for transdermal delivery with targeted and prolonged release of a drug. It also enhances skin permeation of many drugs.
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