IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

SCREENING, IN VITRO ANTIOXIDANT AND IN VIVO ANTIDIABETIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF EUPHORBIA NERIIFOLIA

Makhan Lodhi*, Dr. Brijesh Sirohi, Dr S. K. Lariya

ABSTRACT

Euphorbia neriifolia Linn (E. neriifolia, Euphorbiaceae) is a commonly occurring plant around the dry, rocky, hilly areas of North, Central and South India. The milky latex and leaves of this plant is frequently used by the natives of Central India in case of burn, piles and to treat the deep cracks in soles of legs. This study sought to evaluate the in vitro antioxidant and in vivo antidiabetic potentials of hydroalcoholic extract of leaves of E. neriifolia in diabetic rats. Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenolics and flavonoids were determined by the well-known test protocol available in the literature. The oral antidiabetic activity of the extract (100 and 200mg/kg) was screened against alloxan induced diabetes in rats and glibenclamide was used (600 mcg/kg body weight) as standard drug. The investigational drug was administered for 15 consecutive days, and the effect of the extract on blood glucose levels was studied at regular intervals. At the end of the study, the blood samples were collected from all the animals for biochemical estimation. In this study, Body weight, blood glucose, TC, TG and total protein were measured. The effect of hydroalcoholic extract of E. neriifolia leaves elicited significant reduction in blood glucose, lipid parameters (TC, TG, total protein) and significantly increased body weight at the dose of 200 mg/kg when compared with the diabetic-induced control. From the above results, it is concluded that hydroalcoholic extract of E. neriifolia leaves possesses significant antidiabetic activity in alloxan induced diabetic rats due to presence of various biomarkers.

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