IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

SIMPLE COST EFFECTIVE METHOD DEVELOPMENT FOR THE ESTIMATION OF DAPAGLIFLOZIN IN MARKETED FORMULATION

Roli Shukla*

ABSTRACT

In the present study, an attempt was made to develop a simple, precise and accurate method for the estimation of Dapagliflozin in pharmaceutical dosage form and validate as per International Conference on Harmonization (ICH) guidelines. This Method involves solving of simultaneous equations based on measurement of absorbance at two wavelengths 242 nm ?max of Dapagliflozin in water. Both the drugs obey the Beer’s law in the concentration ranges 2-10µg/ml. % Recovery for both the drugs were in the range of near to 100 indicating excellent accuracy. The methods were precise, with a relative standard deviation of less than 2% for both drugs. The developed methods were validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values.

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