IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

STUDY OF PHYTOCHEMICAL AND IN-VITRO ANTI-DIABETIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF BUTEA MONOSPERMA

Dr. Bhawna Sharma*, Dr. Ruchi Acharya, Aarchi Jain, Aditi Jain, Dr. Peenu Mahendra Joshi,
Dr. Jaswinder Mehta

ABSTRACT

Diabetes mellitus (DM) is a global health problem and the incidence of DM is increasing at alarming rate all over the world. Many Indian medicinal plants have been reported to possess potential antidiabetic activity and could play important role in the management diabetes. Hydroalcoholic extracts of Butea monosperma showed the presence of Flavonoids, Diterpenes, Proteins and Saponins. Total flavonoids content was calculated as quercetin equivalent (mg/100mg) using the equation based on the calibration curve: Y=0.032X + 0.018, R2=0.998, where X is the quercetin equivalent (QE) and Y is the absorbance. The total flavonoids content of the extracts was expressed as percentage of quercetin equivalent per 100 mg dry weight of sample. TFC of hydroalcoholic extract of Butea monosperma showed the content values of 0.828respectively. In vitro anti diabetic activity of Butea monosperma was determined using?-amylase inhibition activity. The Percentage inhibition of Acarbose was found to be 37.19µg/ml and Hydroalcoholic extract of Butea monosperma percentage inhibition was found to be 127.89µg/ml.

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