International Journal of Pharmaceutics & Drug Research

Sunil Kumar Jaiswal*, C. K. Tyagi, Prabhakar Budholiya

ABSTRACT

Ulcer is a common gastrointestinal disorder which is seen among many people. It is basically an inflamed break in the skin or the mucus membrane lining the alimentary tract. Ulceration occurs when there is a disturbance of the normal equilibrium caused by either enhanced aggression or diminished mucosal resistance. It may be due to the regular usage of drugs, irregular food habits, stress, and so forth. Peptic ulcers are a broad term that includes ulcers of digestive tract in the stomach or the duodenum. Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of the most commonly used medicines and proven to be effective for certain disorders. Some people use NSAIDs on daily basis for preventive purpose. But a variety of severe side effects can be induced by NSAIDs. Studies have shown that edible natural ingredients exhibit preventive benefit of gastric ulcer. Therefore present study was designed to evaluate the antiulcer activity of hydroalcoholic extract of Acacia nilotica in rats. Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenolics and flavonoids were determined by the well-known test protocol available in the literature. The total phenolics content of Acacia nilotica extract was (0.586 mg/100mg), followed by flavonoids (0.874mg/100mg) respectively. Further hydroalcoholic extract of 100 and 200mg/kg/p.o significantly (p?0.01) reduced the gastric pH, ulcer index in Indomethacin induced ulcer models in rats. The findings of this study confirmed that Acacia nilotica extract has anti-ulcer pharmacologic activity due to one or more of the secondary metabolites present in it. Therefore, this study validates its anti-ulcer use in Indian folk medicine. Further investigations on isolation of specific phytochemicals and elucidating mechanisms of action are needed.

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