IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

EVALUATION OF IN VIVO HEPATOPROTECTIVE ACTIVITY OF LEAVES EXTRACTS OF ZIZYPHUS XYLOPYRUS (RETZ.) WILLD

Sandeep Jaiswal*, C. K. Tyagi, Prabhakar Budholiya

ABSTRACT

Exploring medicinal plants which are easily available and cheap and do not involve strenuous pharmaceutical production processes appears to have gained worldwide attention as alternative therapeutic agents for the diseases. Consequently, emphasis has been placed on folkloric herbs with high efficacy, low toxicity, and cost-effectiveness. Present Investigation deals with hepatoprotective effect of hydroalcoholic extract of fruit of Zizyphus xylopyrus (Retz.) Willd. Zizyphus xylopyrus fruits are an important medicinal plant which is used in traditional medicine to treat many diseases. Both the test groups i.e. low dose and high dose treated Groups shown dose dependent hepatoprotective activity. The test groups containing the plant extract alone showed an improvement in the liver activity. It clearly indicates that the plant “Zizyphus xylopyrus Fruits” has the hepatoprotective activity. This study showed that Zizyphus xylopyrus Fruits has a significant protective action against the hepatotoxicity induced by the drugs used in the treatment of tuberculosis. The hepatoprotective role of Zizyphus xylopyrus Fruits might be due to its antioxidant potential mechanism suggesting that the extract of plant may be useful to prevent the oxidative stress induced liver damage.

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