EVALUATION OF ANTIDEPRESSANT, MOTOR COORDINATION AND LOCOMOTOR ACTIVITIES OF HYDROALCOHOLIC EXTRACT OF BAMBUSA VULGARIS LEAVES IN MICE
Anish kumar1, Brijesh Sirohi*1, Prabhat Jain2, Nishpa kumari1
ABSTRACT
Bambusa vulgaris (B. Vulgaris, Poaceae) used in Ayurveda for paralytic complaints, inflammatory disorders and externally to skin disorders. It has various medicinal uses with good nutritional composition and a rich source of vitamins, proteins, amino acid, beta-carotene and phenolic compounds. The aim of present study was to investigate the anti-depressant (by Tail suspension test and Forced swimming test), motor coordination (by Rotarod method) and locomotor (with an actophotometer) activities of hydroalcoholic leaves extract of B. Vulgaris in experimental animals. The study revealed that the extracts (750mg/kg, p.o.) were able to increase the immobility time of rats in a dose-dependent manner when subjected to both Tail suspension and Forced swim tests and the results were similar to that of standard drug Diazepam (2mg/kg, i.p). B. Vulgaris hydroalcoholic leaves extract (750mg/kg) showed mild reduction in locomotor and motor coordination activity. Therefore, B. Vulgaris may be served as a potential resource for natural sychotherapeutic agent against depression and mood disorders.
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