IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

Development and Evaluation of Fast Dissolving Tablets of Metformin HCl using different crosslinked cellulose

Deepshikha Gunwan*, Prabhakar Budholiya, Hemant Kumar Sharma

ABSTRACT

In the current research work was to developed immidiate release tablets of metformin HCl with improved dissolution rate and faster disintegration and dissolution characteristics with increased bioavailability. The fast dissolving tablets of metformin HCl were prepared by direct compression methods and blend was evaluated for the pre-compression parameters such as bulk density, compressibility, angle of repose etc. The tablets were prepared by using cross-carmellose sodium and primallose as superdisintegrants in various concentration along with lubricant and glidant. Six different formulations were prepared and evaluated different parameters as per IP. In-vitro dissolution studies are accomplished by utilizing phosphate buffer pH 6.8 at 75 rpm by paddle dissolution method. Among the all formulation F5containing of croscarmellose sodium was found to be appropriate and has shown a disintegration time 25 sec. The stability studies were performed for three months (accelerated studies) as per ICH guidelines. The optimized formulation (F5) indicates no variations for the parameters of tablets and it was stable for the specific time period.

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