Formulation Development and Evaluation of Ethosomal Gel of Amphotericin B for Treatment of Fungal Infections
Rahul Paroliya*, Nishi Prakash Jain, Abhishek Banke
ABSTRACT
Ethosomes are novel vesicular delivery system which has great potential for topical and transdermal delivery of various drugs. Amphotericin B is a polyene antifungal drug used intravenously for systemic fungal infections. It has severe and potentially lethal side effects, therefore, it has been limited use in clinical. Ethosomes were formulated using phospholipid, cholesterol, ethanol, polyethylene glycol and purified water by cold method. Ethosomes having for evaluated like shape, vesicle size, optical microscopy, entrapment efficiency and in-vitro release study. F3 have better drug entrapment efficiency than the other formulation. The best formulation (F3) was used to prepare gel by using carbopol 934 as a gelling agent. The ethosomes were entrapped in gel matrix of carbopol 934 in different concentration 0.5%, 1.00% and 1.5% w/w. FT-IR studies revealed no interaction between the drug and excipients. The formulated gel formulation was evaluated with parameter pH, viscosity, spreadability, in-vitro release test, washability, extrudability study and stability studies. The formulation EG2 have better in-vitro drug release profile which contains carbopol 934 concentration 1%w/w. The present work also focuses on making the formulation more pharmaceutically acceptable.
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