Formulation, Development and Evaluation of Gastroretentive Floating Tablets of Saxagliptin for Effective Treatment of Type II Diabetes
Nikita Thakur1*, BK Dubey2, GK Pandey3, Suresh Dhakar4, Prabhat Kumar Jain5
ABSTRACT
The objective of this study was to develop a floating tablet of Saxagliptin. Saxagliptin is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Nine formulations of Saxagliptin tablets are prepared by direct compression method using HPMC, lactose, talc, citric acid and sodium bicarbonate as polymers and excipients. PVP K 30 used as granulating agent. The formulations were evaluated for physical parameters like thickness, hardness, friability, uniformity of weight, drug content, buoyancy time, and drug release mechanism. The formulations were optimized on the basis of buoyancy time and in vitro drug release. The prepared tablets were evaluated for physicochemical parameters and found to be within range. The optimized formulation was found to be F7 which released 99.78 % of drug in 12 hrs. and follow first order kinetics.
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