International Journal of Pharmaceutics & Drug Research

Sushma Gour*, C.K. Tyagi, Hemant Kumar Sharma, Prabhakar Budholiya

ABSTRACT

The aim of the study was to evaluate the antipyretic activity of hydroalcoholic leaf extract of Morus Alba Linn using Brewer’s yeastinduced pyrexia model in wister strain albino rats. The hydroalcoholic leaf extract at a dose of 250mg/kg & 500 mg/kg were evaluated for antipyretic activity. The extract of Morus alba plant showed a significant (P < 0.01) dose dependent antipyretic effect in yeast induced elevation of rectal temperature in experimental rats when compared with the standard paracetamol. So It can be recommended for further studies. The extracts were also phytochemically screened for alkaloids, tannins, saponins, flavonoids, terpenoids, quinones and anthraquinones and quantitative analysis of total phenolic, flavonoids and alkaloid were determined by the well-known test protocol available in the literature. 24 albino rats weighing 150-200g were used. They were divided in to four groups of six rats each. Group one serve as control (n=6) and was given normal saline, group two serves as standard group (n=6) was given 150mg/kg of paracetamol, while groups three and four serves as test groups were treated with 250mg/kg and 500mg/kg (n=6) of plant extract respectively. A 15% suspension of 10ml/kg of brewer’s yeast was injected subcutaneously to induce fever in all the experimental animals. After 24hrs, the rectal temperature was taken and the animals were administered Morus alba (250mg/kg, 500 mg/kg) and paracetamol (standard group, 150mg/kg) orally. The body temperature of the rats was measured rectally over a period of 4hours.Morus alba (250mg/kg, 500 mg/kg) significantly reduced yeast induced pyrexia when compared with the group two (paracetamol, 150mg/kg) Thus, this experiment shows that the antipyretic effect of Morus alba is dose dependent and the effect is as a result of the flavonoid component of the extract.

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