IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

VALIDATED SPECTROPHOMETRIC METHOD FOR THE ESTIMATION OF CLINDAMYCIN IN PHARMACEUTICAL FORMULATION VIA ION-PAIR REACTION USING METHYL ORANGE DYE

Dr. Reeta Bamnela1, Prabhat Jain*2, Versha Nateriya1, Yogeshwari Dhruv1

ABSTRACT

In present work a simple, accurate, precise, reproducible, method was developed for the estimation of Clindamycin in bulk drug and pharmaceutical formulation by spectrophotometer. Spectrophotometric methods are described for determination of Clindamycin in bulk and pharmaceutical dosage forms using methyl orange as chromogenic agents. Calibration curves have correlation coefficients (r) 0.999 indicating good linearity over a concentration range of 10-50 ?g/mL. The %RSD was less than 2%, showing high degree of precision of the proposed method. The methods were satisfactory applied for the determination of drugs in both bulk and pharmaceutical dosage forms.

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