FORMULATION AND EVALUATION OF ETHOSOMAL GEL OF MICONAZOLE NITRATE FOR FUNGAL INFECTION BY COLD METHOD
Abhishek Singh Chauhan1, Girijesh Kumar Pandey1, Amit Joshi1, B.K Dubey2, Prabhat Jain3
ABSTRACT
The present study investigates the entrapment of miconazole in ethosomal vesicles prepared by cold method. The composition includes phospholipid, ethanol and polyethylene glycol. Drug entrapment efficiency (DEE), invitro drug diffusion studies, FT-IR and stability studies of the prepared ethosomes were investigated. Vesicle size and zeta potential of the ethosomes were measured by photon correlation spectroscopy using a Malvern Zetasizer. Invitro drug release studies were performed using modified franz diffusion cell in phosphate buffer, pH 7.4 for 8 h while drug content was determined by UV. DEE was ranked from 72.23±0.19 to 86.69±0.12 %. Highest DEE was seen with F4 ethosomal formulation with a vesicle size of 178.5±5.6nm. FT-IR studies confirmed that there was no chemical interaction between drug and excipients used in the formulation. The selected formulation (F4) was incorporated in to gel using Carbopol 934 and evaluated for pH, washability, extrudability study, spreadability, viscosity, % assay and % drug release. Selected ethosomal gel (EG2) showed a drug content of 95.56±0.12 % and drug release of 95.45±2.45 % in 8 hrs. This study disclosed that EG2resides at targeted site for a relatively longer period of time thereby signifying the improved patient compliance.
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