DEVELOPMENT AND EVALUATION OF ONDANSETRON HCL MICROBALLOONS FOR TREATMENT OF EMESIS
Akansha Rai1, Surendra Dangi*1,2, Nidhi Jain1, Subhendu S. Mishra3
ABSTRACT
In present study an attempt was made to prepare microballons of ondansetron by emulsion solvent diffusion method for sustained delivery by using polymers like Eudragit RS 100 and HPMC. The extend of the drug release for about 6 hrs in to the upper GIT, this may the increase absorption and their improved bioavailability. The amount of drug release was determined by USP Dissolution test apparatus was found to range from 81.32 % to 89.34 % from all formulation. Formulation F6 containing HPMC and Eudragit polymer blend show the better release study among other formulation. Scanning electron microscopy, it was observed that, microballons were found to be spherical in shape with smooth surface texture. Among all formulations, F6 shows appropriate drug release rate 89.34 % in 6 hrs. which is considered as the best formulation.
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