FAST DISSOLVING ORAL FILM: A MODERN DEVELOPMENT IN DRUG DELIVERY SYSTEM
Mohd. Adil Khan*1, Girijesh Kumar Pandey1, Amit Joshi1, B.K. Dubey2, Amit Kumar Jain2, Geeta Parkhe3
ABSTRACT
Patient conformity always remains the major concern of research for all researchers working in the ground of pharmacy and specially pharmaceutics. Over the last few decades, propensity toward innovative drug delivery systems have majorly enlarged attempts to make sure worth, safety and patient acceptability, thereby increasing the product patent life cycle. As innovation and expansion of new chemical agents is a complex, costly and time consuming process, so current trends are changing toward designing and developing novel drug delivery systems for existing drugs. The FDDFs includes the mouth dissolving tablets, mouth dissolving thin films. These fast disintegrating films have advantage over fast disintegrating tablets as the latter are connected with the risks of choking and friability. It is a robust form of DDS where the film is placed on the top or the bottom of the tongue. When place on the tongue, this film dissolves immediately, releasing the drug which dissolves in the saliva. Some drugs are engrossed from the mouth, pharynx and esophagus as the saliva passes down into the stomach as a result enhancing drug bioavailability, no peril of choking, providing fine mouth feel. Generally, hydrophilic polymers along with added excipients are used for preparing FDOFs. FDOFs have potential for business and market utilization because of their many of benefits over orally disintegrating tablets. So it’s gaining the interest of large number of pharmaceutical industries. Additionally, the market view of this novel dosage form is also targeted. This present review attempts to discusses oral mucosa, focus on benefits, formulation ingredients, composition, approaches for formulation and evaluation, future prospects of FDOFs.
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